REM sleep behavior disorders in neurodegenerative diseases
Keywords:
sleep, RBD, neurodegenerative diseasesAbstract
Sleep is one of the most important physiological phenomena in a person's life and so far remains perhaps the most undiscovered one-third of it. It is part of the natural circadian homeostasis. Many different structures located in different parts of the central nervous system are important for its formation. In certain neurological conditions, specific types of sleep disorders are observed, which in some cases reveal common features in their pathology. Some of the sleep disorders may be the first symptom in a number of neurological conditions. In other cases, they may lead to an increased risk for some pathological processes.
Neurodegenerative diseases affect different parts of the nervous system, and therefore almost all of them affect structures responsible for normal sleep. Behavioural disorders during the REM phase (RBD) is a condition that may be a concomitant symptom, but may also be one of the first manifestations of a developing pathological process. This type of pathology largely reveals the common features of this type of diseases, which makes it possible to create new hypotheses in their general etiology and open up new therapeutic options. Almost any proteinopathy in the neurodegenerative diseases leads to the destruction of hypothalamic neurons and involvement of the brainstem nuclei, which alter the architectonics of sleep.
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Copyright (c) 2020 Tsvetomir Asenov, I. Milanov, P. Kolev, D. Bogdanova
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