Възможно ли е “прерастване” на Есенциалния тремор към треморна форма на Паркинсонова болест или това са две отделни заболявания?
Ключови думи:
Есенциален тремор, Паркинсонова болест, коморбидностАбстракт
В световната литература съществува противоречива информация относно това дали пациенти с Есенциален тремор (ЕТ) могат да развият впоследствие Паркинсонова болест (ПБ). Все още е трудно да се изкаже становище дали има коморбидност между двете заболявания или са две отделни нозологии. Другият въпрос е дали ЕТ е “прераснал” към ПБ поради съществуващ по-голям риск при наличие на ЕТ да се развие друго невродегенеративно заболяване. Необходимо е провеждане на задълбочени клинични проучвания, което изисква продължително наблюдение на групи пациенти и провеждане на специализирани изследвания. Необходимо е да се разработят и използват специфични патофизиологични, генетични и лабораторни маркери. Правилното разпознаването на двете заболявания предполага адекватно лечение, забавяне прогресията на болестта и осигуряване на по-добро качество на живот на пациентите и техните близки.
Литература
Bogdanova, D., Milanov, I. Esentsialen tremor i Parkinsonova bolest – pregled na literaturata i prosledyavane na 114 bolnitsi. Dvigatelni narusheniya, 2004, 1, 2, 36-42.
Georgiev, D., Milanov, I., Chipilski, L. Aktualni problemi pri nyakoi ekstrapiramidni zabolyavaniya. Sofiya : “AS” OOD, 1996, 143 str.
Milanov, I. Sŭvremenni razbiraniya za patogeneza na Parkinsonovata bolest. Dvigatelni narusheniya, 2014, 11, 2, 13-22.
Milanov, I. Uchebnik po nevrologiya, Meditsina i fizkultura, 2012, 1056 str.
Cheshire, P., Pfeiffer, F. Is α-synuclein rising to the surface as a diagnostic biomarker for Parkinson disease? Neurology, 2013, 81, 18, 1568-1579.
Abraham, A., Drory, V., Influence of serum uric acid levels on prognosis and survival in amyotrophic lateral sclerosis: a meta-analysis, J. Neurol, 2014, 261,1133-1138.
Algarni, M., Fasano, A. The overlap between Essential tremor and Parkinson disease, Parkinsonism Relat Disord. 46, 2018, S101eS104.
Antonini, A. Continuous dopaminergic stimulation – from theory to clinical practice. Parkinsonism Relat. Disord., 2007, 13 Suppl., 24-28.
Barbosa, R., Mendonca, M., Ladeira, F., Miguel, R., Bugalho, P. Probable REM-sleep behavior disorder and dysautonomic symptoms in essential tremor. Tremor Other Hyperkinet Mov, 2017, 7.
Brooks, D. Dopamine agonists: their role in the treatment of Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 2000, 68, 685-689.
Central Spain Study Group. Risk of incident Parkinson’s disease and parkinsonism in essential tremor: a population based study. J Neurol Neurosurg Psychiatry. 2008, 80, 423-425.
Chen, H., Yuan, L., Song, Z., Deng, X., Yang, Y, Gong, L., Zi, X., Deng, H. Genetic analysis of LRRK1 and LRRK2 variants in essential tremor patients, Genet Test Mol Biomarkers. 22, 6, 2018, 398-402.
Geraghty, J., Jankovic, J., Zetusky, W. Association between essential tremor and Parkinson’s disease. Ann Neurol. 1985, 17, 329-333.
Gerasimou, G., Costa, D., Papanastasiou, E., Bostanjiopoulou, S., Arnaoutoglou, M., Moralidis, E. SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson’s disease? Ann Nucl Med. 2012, 26, 337-344.
Hopfner, F., Deuschl, G. Is essential tremor a single entity? Eur. J. Neurol. 2018, 25, 1, 71-82.
Jimenez-Shahed, J., Diamond, A., Vuong, K., Jankovic, J. Characteristics of Parkinson’s disease in patients with childhood-onset essential tremor. Mov Disord. 2005, 20, S169.
Jin, L., Wang, J., Wang, C., Lian, D. Combined visualization of nigrosome-1 and neuromelanin in the substantia nigra using 3T MRI for the differential diagnosis of essential tremor and de novo Parkinson’s disease, Front. Neurol. 2019, 10, 100.
Lee, C., Yoon, J., Park, J., Hong, J., Sunwoo, M. Uric acid level may not be reduced in essential tremor, Int J Neurosci. 2018, 128, 12, 1163-1167.
Lou, J., Jankovic, J. Essential tremor: clinical correlates in 350 patients. Neurology, 1991, 41, 234-238.
Louis, E. Chapter 16: essential tremor and the cerebellum, Handbook Clinical Neurol. 155 (3rd series). 2018, 245-258.
Louis, E., Faust, P., Vonsattel, J., Honig, L. Torpedoes in Parkinson’s disease, Alzheimer’s disease, essential tremor and control brains. Mov Disord. 2009, 24, 1600-1605.
Louis, E., Faust, P., Vonsattel, J., Honig, L. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007, 130, 3297-3307.
Lu M-K, Chen C-M, Duann J-R, Ziemann U, Chen J-C, Chiou S-M. Investigation of motor cortical plasticity and corticospinal tract diffusion tensor imaging in patients with Parkinsons disease and essential tremor. PLoS-One, 2016, 11.
Muthuraman, M., Raethjen, J., Koirala, N. Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain 2018, 141,1770-1781.
Shill, H., Adler, C., Sabbagh, M., Connor, D., Caviness, J., Hentz, J. Pathologic findings in prospectively ascertained essential tremor subjects. Neurology 2008, 70, 1452-1455.
Stefansson, H., Steinberg, S., Petursson, H., Gustafsson, O., Gudjonsdottir, I., Jonsdottir, G. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet, 2009, 41, 277-279.
Tarakad, A., Jankovic, J. Essential tremor and Parkinson’s disease: exploring the relationship, Tremor Other Hyperkinet Mov. 2019, 8, 589.
Vilarin˜o-Gu, C., Wider, C., Ross, O., Jasinska-Myga, B., Kachergus, J., Cobb, S. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics. 2010, 11, 401-408.
Wu, T., Hallett, M. The cerebellum in Parkinson’s disease. Brain. 2013, 136, 696-709.
##submission.downloads##
Публикуван
Как да цитирате?
Брой
Раздел (Секция)
Лиценз
Copyright (c) 2020 Двигателни нарушения

Публикация с Creative Commons Attribution 4.0 International License.