Клинико-епидемиологични проучвания при множествена склероза
Ключови думи:
множествена склероза, епидемиология, разпространение, рискови факториАбстракт
Множествената склероза е хронично, възпалително, автоимунно, демиелинизиращо и дегенеративно заболяване на централната нервна система и е водеща причина за неврологичен дефицит сред младото, трудоспособно население в световен мащаб. Засяга предимно млади хора с пик във възрастовата група 20-40 години и преобладава сред женския пол. Заболяването е социално-значимо, влошава качеството на живот на засегнатите индивиди, натоварва финансово, както болните и техните близки, така и обществото и здравната система като цяло и е едно от най-проучваните в епидемиологично отношение неврологични заболявания. Характеризира се с неравномерно географско разпространение и въпреки, че точната причина за заболяването не е изяснена, смята се че етиологията е мултифакторна. Множествената склероза се развива при генетично предразположени индивиди под влияние на рискови фактори от околната среда.
Литература
Kalafatova, O.I. Klinichesko-epidemiologichno izsledvane na diseminiranata skleroza. Disertatsiya, Sofiya, 1983.
Milanov, I. Mnozhestvena skleroza i avtoimunni demielinizirashti zabolyavaniya na tsentralnata nervna sistema. Meditsina i fizkultura, Sofiya, 2014, 319 str.
Natsionalen konsensus za diagnostika i lechenie na mnozhestvena skleroza. Dvigatelni narusheniya, 2019, 16, dopŭlnenie 1, 59 str.
Topalov, N. Kliniko-epidemiologichno izsledvane na mnozhestvenata skleroza v Bŭlgariya. Disertatsiya, Sofiya, 1999.
Alonso, A., Hernán, M.A. Temporal trends in the incidence of multiple sclerosis. Neurology, 2008, 71, 129-135.
Ascherio, A., Munger, K.L. Epidemiology of multiple sclerosis: From risk factors to prevention – an update. Seminars in Neurology., 2016, 36, 103-114.
Berg-Hansen, P., Celius, E.G. Socio-economic factors and immigrant population studies of multiple sclerosis. Acta Neurologica Scandinavica, 2015, 132, supplement 199, 37-41.
Bjørnevik, K., Chitnis, T., Ascherio, A., Munger, K.L. Polyunsaturated fatty acids and the risk of multiple sclerosis. Multiple Sclerosis, 2017, 23, 1830-1838.
Bjørnevik, K., Riise, T., Cortese, M., Holmøy, T., Kampman, M.T., Magalhaes, S., Myhr, K.M., Wolfson, C., Pugliatti, M. Level of education and multiple sclerosis risk after adjustmentfor known risk factors: the EnvIMS study. Multiple Sclerosis, 2016, 22, 104-111.
Correale, J., Gaitán, M.I. Multiple scle-rosis and environmental factors: the role of vitamin D, parasites, and Epstein-Barr virus infection. Acta Neurologica Scandinavica, 2015, 132, supplement 199, 46-55.
Cristiano, E., Rojas, J.I. Multiple sclerosis epidemiology in Latin America: an updated survey. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2017, 3, 2, 1-7.
Dobson, R., Giovannoni, G., Ramago-palan, S. The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude. Journal of Neurology, Neurosurgery, and Psychiatry, 2013, 84, 427-432.
Dobson, R., Giovannoni, G. Multiple sclerosis – a review. European Journal of Neurology, 2019, 26, 27-40.
Eliasdottir, O., Hildeman, A., Longfils, M., Nerman, O., Lycke, J. A nationwide survey of the influence of month of birth on the risk of developing multiple sclerosis in Sweden and Iceland. Journal of Neurology, 2018, 265, 108-114.
Federation MSI. Atlas of MS 2013: Mapping Multiple Sclerosis around the world: 2013. Available at: http://www.atlasofms.org. Accessed February 23, 2020.
GBD 2016 Multiple Sclerosis Collabo-rators. Global, regional and national burden of multiple sclerosis 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 2019, 18, 269-285.
Georgiev, D., Milanov, I., Tzonev, V., Kalafatova, O. The epidemiology of multiple sclerosis in Sofia. In: Firnhaber, W., Lauer, K., eds.,, Multiple Sclerosis in Europe: An Epidemiological Update, Darmstadt, Leuchtturm- Verlag/LTV Press, 1994, 322-325.
Goodin, D.S. The epidemiology of multiple sclerosis: insights to a causal cascade. Handbook of Clinical Neurology, 2016, 138, 173-206.
Goulden, R., Ibrahim, T., Wolfson, C. Is high socio-economic status a risk factor for multiple sclerosis? A systematic review. European Journal of Neurology, 2015, 22, 899-911.
Grzegorski, T., Losy, J. Multiple sclerosis – the remarkable story of a baffling disease. Reviews in the Neurosciences, 2019, 30, 511-526.
Guillemin, F., Baumann, C., Epstein, J., Kerschen, P., Garot, T., Mathey, G., Debouverie, M. Older age at multiple scle-rosis onset is an independent factor of poor prognosis: a population-based cohort study. Neuroepidemiology, 2017, 48, 179-187.
Hedström, A.K., Olsson, T., Alfredsson, L. Body mass index during adolescence, rather than childhood, is critical in determining MS risk. Multiple Sclerosis, 2016, 22, 878-883.
Hedström, A.K., Mowry, E.M., Gian-francesco, M.A., Shao, X., Schaefer, C.A., Shen, L., Olsson, T., Barcellos, L.F., Al-fredsson, L. High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. Journal of Neurology, Neurosurgery, and Psychiatry, 2016, 87, 454-460.
Kasim, K. Basic concepts of modern epidemiology: epidemiology and research. LAP Lambert Academic Publishing, 2012.
Kavaliunas, A., Manouchehrinia, A., Stawiarz, L., Ramanujam, R., Agholme, J., Hedström, A.K., Beiki, O., Glaser, A., Hil-lert, J. Importance of early treatment initiation in the clinical course of multiple sclerosis. Multiple Sclerosis, 2017, 23, 1233-1240.
Koch-Henriksen, N., Sørensen, P.S. Why does the north-south gradient of inci-dence of multiple sclerosis seem to have disappeared on the Northern hemisphere? Journal of the Neurological Sciences, 2011, 311, 58-63.
Leray, E., Moreau, T., Fromont, A., Edan, G. Epidemiology of multiple sclerosis. Revue Neurologique (Paris), 2016, 172, 3-13.
Magyari, M. Gender differences in multiple sclerosis epidemiology and treatment response. Danish Medical Journal, 2016, 63, 3, 1-18.
Melcon, M.O., Correale, J., Melcon, C.M. Is it time for a new global classification of multiple sclerosis? Journal of the Neurological Sciences, 2014, 344, 171-181.
Michel, L. Environmental factors in the development of multiple sclerosis. Revue Neurologique (Paris), 2018, 174, 372-377.
Milanov, I., Georgiev, D., Kmetska, K., Jordanova, L., Topalov, N. Prevalence of multiple sclerosis in Bulgaria. Neuroe-pidemiology, 1997, 16, 304-307.
Negrotto, L., Correale, J. Evolution of multiple sclerosis prevalence and phenotype in Latin America. Multiple Sclerosis and Related Disorders, 2018, 22, 97-102.
Nouri, H., Tabesh, H., Saboori, M., Sohrabi, K., Mirhosseini, F., Hosseinzadeh Anvar, Z., Sharifkhah, M., Hosseinzadeh Anvar, S., Shaygannejad, V. Protective and risk factors in multiple sclerosis. International Journal of Medical Reviews, 2019.
Olsson, T., Barcellos, L.F., Alfredsson, L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nature Reviews Neurology, 2017, 13, 25-36.
Pierrot-Deseilligny, C., Souberbielle, J.C. Vitamin D and multiple sclerosis: an update. Multiple Sclerosis and Related Disorders, 2017, 14, 35-45.
Rivera, V.M. Multiple sclerosis: a global concern with multiple challenges in an era of advanced therapeutic complex molecules and biological medicines. Biomedicines, 2018, 6, 112, 1-8.
Scalfari, A., Knappertz, V., Cutter, G., Goodin, D.S., Ashton, R., Ebers, G.C. Mortality in patients with multiple sclerosis. Neurology, 2012, 81, 184-192.
Thompson, A.J., Banwell, B.L., Barkhof, F., Carroll, W.M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Fredman, M.S., Fujihara, K., Galetta, S.L., Hartung, H.P., Kappos, L., Lublin, F.D., Marrie, R.A., Miller, A.E., Miller, D.H., Montalban, X., Mowry, E.M., Sorensen, P.S., Tintoré, M., Traboulsee, A.L., Trojano, M., Uitdehaag, B.M., Vukusic, S., Waubant, E., Weinshenker, B.G., Reingold, S.C., Cohen, J.A. 6, 2, 51-Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. The Lancet Neurology, 2018, 17, 162-173.
Thompson, A.J., Baranzini, S.E., Geurts, J., Hemmer, B., Ciccarelli, O. Multiple sclerosis. The Lancet, 2018, 391, 1622-1636.
Yamout, B.I., Alroughani, R. Multiple sclerosis. Seminars in Neurology, 2018, 38, 212-225.
##submission.downloads##
Публикуван
Как да цитирате?
Брой
Раздел (Секция)
Лиценз
Copyright (c) 2020 Двигателни нарушения
Публикация с Creative Commons Attribution 4.0 International License.
